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Review
. 2009 Oct;9(11):1272-83.
doi: 10.2174/138955709789878105.

Inhibitors of HMG-CoA Reductase: Current and Future Prospects

Narender Singh  1 , Joaquín Tamariz, Germán Chamorro, Jose L Medina-Franco
Affiliations
Review

Inhibitors of HMG-CoA Reductase: Current and Future Prospects

Narender Singh et al. Mini Rev Med Chem. 2009 Oct.

Abstract

High levels of cholesterol are a primary risk factor in the development of cardiovascular diseases. In this review, we have summarized the structural, chemical and computational aspects of hypocholesterolemic drugs, both statins and non-statins, that target enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) to block cholesterol biosynthesis.

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