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. 1991 Jan 31;174(2):1035-42.
doi: 10.1016/0006-291x(91)91523-f.

The structure of the brain-specific rat aldolase C gene and its regional expression

T Mukai  1 , H Yatsuki, S Masuko, Y Arai, K Joh, K Hori
Affiliations

The structure of the brain-specific rat aldolase C gene and its regional expression

T Mukai et al. Biochem Biophys Res Commun. .

Abstract

The rat aldolase C gene was isolated from a rat genomic DNA library. This gene comprises 9 exons and spans 3590 base pairs. A single copy of the gene occurs per haploid rat genome. The initiation of transcription occurs at two different sites. The cellular localization of aldolase C mRNA was determined in the central nervous system along with aldolase A mRNA by in situ hybridization. The result indicates the predominant expression of this gene in Purkinje cells of the cerebellar cortex, where aldolase A mRNA was rather repressed.

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