Tetracaine (ametop) compared to placebo for reducing pain associated with intramuscular injection of palivizumab (synagis)
- PMID: 19931151
- DOI: 10.1016/j.pedn.2009.05.007
Tetracaine (ametop) compared to placebo for reducing pain associated with intramuscular injection of palivizumab (synagis)
Abstract
Infants receive many painful immunizations before they are 2 years old. The purpose of this study was to evaluate if topical tetracaine reduces the pain of intramuscular palivizumab compared to placebo. There were two study injections, one with tetracaine and one with placebo. Pain was scored by their parents and a pediatric nurse. Topical tetracaine was not associated with a significant reduction in pain score, although it did lead to faster recovery times. Additional pain-reduction strategies are required.
Similar articles
-
EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children.Pediatrics. 2008 Jun;121(6):e1591-8. doi: 10.1542/peds.2007-3104. Epub 2008 May 5. Pediatrics. 2008. PMID: 18458035 Clinical Trial.
-
Topical amethocaine gel 4% for intramuscular injection in term neonates: a double-blind, placebo-controlled, randomized trial.Clin Ther. 2008 Jan;30(1):166-74. doi: 10.1016/j.clinthera.2008.01.018. Clin Ther. 2008. PMID: 18343253 Clinical Trial.
-
Warm lidocaine/tetracaine patch versus placebo before pediatric intravenous cannulation: a randomized controlled trial.Ann Emerg Med. 2008 Jul;52(1):41-7. doi: 10.1016/j.annemergmed.2008.01.336. Epub 2008 Apr 8. Ann Emerg Med. 2008. PMID: 18395934 Clinical Trial.
-
Palivizumab for respiratory syncytial virus prophylaxis.J Pediatr Health Care. 1999 Jul-Aug;13(4):191-5; quiz 196-7. doi: 10.1016/S0891-5245(99)90039-1. J Pediatr Health Care. 1999. PMID: 10690084 Review.
-
Question 2: does topical local anaesthetic reduce pain from vaccinations in infants?Arch Dis Child. 2014 Nov;99(11):1057-8. doi: 10.1136/archdischild-2014-306561. Epub 2014 Jul 8. Arch Dis Child. 2014. PMID: 25005524 Review. No abstract available.
Cited by
-
Improving the treatment of infant pain.Curr Opin Support Palliat Care. 2017 Jun;11(2):112-117. doi: 10.1097/SPC.0000000000000270. Curr Opin Support Palliat Care. 2017. PMID: 28375883 Free PMC article. Review.
-
Nociceptive brain activity as a measure of analgesic efficacy in infants.Sci Transl Med. 2017 May 3;9(388):eaah6122. doi: 10.1126/scitranslmed.aah6122. Sci Transl Med. 2017. PMID: 28469039 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical