Comment
doi: 10.1016/j.immuni.2009.10.004.
Toll-like receptor 9: AEP takes control
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- PMID: 19932067
- DOI: 10.1016/j.immuni.2009.10.004
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Comment
Toll-like receptor 9: AEP takes control
Immunity.
.
Free article
Abstract
Toll-like receptor 9 (TLR9) requires proteolytic maturation to acquire signaling capacity; however, the involved protease(s) is unclear. In this issue of Immunity, Sepulveda et al. (2009) demonstrate that in dendritic cells, asparaginyl endopeptidase is a key protease that controls TLR9 maturation.
Comment on
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Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells.Immunity. 2009 Nov 20;31(5):737-48. doi: 10.1016/j.immuni.2009.09.013. Epub 2009 Oct 29. Immunity. 2009. PMID: 19879164
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