Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Jan;72(1):43-53.
doi: 10.1016/0014-4894(91)90119-h.

Trypanosoma cruzi: shedding of surface antigens as membrane vesicles

M F Gonçalves  1 , E S Umezawa, A M Katzin, W de Souza, M J Alves, B Zingales, W Colli
Affiliations

Trypanosoma cruzi: shedding of surface antigens as membrane vesicles

M F Gonçalves et al. Exp Parasitol. 1991 Jan.

Abstract

Tissue culture-derived trypomastigotes from Trypanosoma cruzi spontaneously shed surface antigens into the culture medium. The shedding is a temperature- and time-dependent phenomenon and is independent of the presence of proteins or immune serum in the medium. The analysis of this process in four strains (Y, YuYu, CA1, and RA) showed differences in the amounts of polypeptides released. However, for all strains the liberation of the entire set of surface polypeptides ranging in molecular mass from 70 to 150 kDa was observed. Biochemical and electron microscopic data strongly suggest that most of the surface antigens are released as plasma membrane vesicles, ranging from 20 to 80 nm in diameter.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • The state of the art of extracellular vesicle research in protozoan infection.
    Wang X, Chen J, Zheng J. Wang X, et al. Front Genet. 2022 Aug 12;13:941561. doi: 10.3389/fgene.2022.941561. eCollection 2022. Front Genet. 2022. PMID: 36035188 Free PMC article. Review.
  • Potential Roles of Fungal Extracellular Vesicles during Infection.
    Joffe LS, Nimrichter L, Rodrigues ML, Del Poeta M. Joffe LS, et al. mSphere. 2016 Jun 29;1(4):e00099-16. doi: 10.1128/mSphere.00099-16. eCollection 2016 Jul-Aug. mSphere. 2016. PMID: 27390779 Free PMC article. Review.
  • Biological properties of extracellular vesicles and their physiological functions.
    Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Yáñez-Mó M, et al. J Extracell Vesicles. 2015 May 14;4:27066. doi: 10.3402/jev.v4.27066. eCollection 2015. J Extracell Vesicles. 2015. PMID: 25979354 Free PMC article.
  • Extracellular Vesicles from Naegleria fowleri Induce IL-8 Response in THP-1 Macrophage.
    Lertjuthaporn S, Somkird J, Lekmanee K, Atipimonpat A, Sukapirom K, Sawasdipokin H, Tiewcharoen S, Pattanapanyasat K, Khowawisetsut L. Lertjuthaporn S, et al. Pathogens. 2022 May 30;11(6):632. doi: 10.3390/pathogens11060632. Pathogens. 2022. PMID: 35745486 Free PMC article.
  • A profile of research on the parasitic trypanosomatids and the diseases they cause.
    Horn D. Horn D. PLoS Negl Trop Dis. 2022 Jan 13;16(1):e0010040. doi: 10.1371/journal.pntd.0010040. eCollection 2022 Jan. PLoS Negl Trop Dis. 2022. PMID: 35025891 Free PMC article. Review.
See all "Cited by" articles

Publication types

LinkOut - more resources