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Case Reports
. 2010 Mar;31(1):83-4.
doi: 10.1097/PAF.0b013e3181c21c10.

Accidental intrathecal administration of vincristine

Adriana D'Addario  1 , Juan Galuppo, Carlos Navari, Marcelo Schultz, Nélida Cuello, Juan C Troncoso, Miguel Angel Riudavets
Affiliations
Case Reports

Accidental intrathecal administration of vincristine

Adriana D'Addario et al. Am J Forensic Med Pathol. 2010 Mar.

Abstract

We describe a case of accidental intrathecal administration of vincristine in a 33-year-old man with clinical diagnosis of acute lymphocytic leukemia. The patient died 20 days after receiving the drug. Clinically, the patient developed acute ascending paralysis with motor and sensory dysfunctions, and respiratory failure. Neuropathological investigation revealed lesions in spinal cord, roots, and cerebellum characterized by rarefaction of the neuropil, axonal, and myelin degeneration, accompanied by macrophagic infiltration.

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