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Comment
. 2009 Dec;8(12):923-4.
doi: 10.1038/nmat2577.

Tissue engineering: Function follows form

James C Iatridis
Comment

Tissue engineering: Function follows form

James C Iatridis. Nat Mater. 2009 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Spine anatomy. The intervertebral disc supports large loading on the spine while allowing mobility, but is a common source of pain, particularly when the gelatinous nucleus pulposus (shown in blue) is forced through a weakened part of the annulus fibrosus (shown in purple). The ubiquitous problem of lower back pain provides motivation for improved repair techniques including engineering of annulus fibrosus replacements.
Figure 2
Figure 2
Intervertebral disc structure. The annulus fibrosus is a hierarchical structure with many levels of complexity within and between annular layers in the native tissue. Successful tissue engineering of the annulus fibrosus requires improved understanding of the interactions between fibres and cells, and the interfaces between annular layers. Blue: DNA in cells; orange: collagen type I; green: collagen type VI. The immunohistology image was obtained in collaboration with Dr Casey Korecki and Dr Marc Levenston.
See this image and copyright information in PMC

Comment on

References

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    1. Nerurkar NL, et al. Nature Mater. 2009;8:986–992. - PMC - PubMed
    1. Iatridis JC, Michalek AJ, Purmessur D, Korecki CL. Cell. Mol. Bioeng. 2009;2:437–447. - PMC - PubMed
    1. Ruan D, et al. Lancet. 2007;369:993–999. - PubMed
    1. Kandel R, Roberts S, Urban JP. Eur. Spine J. 2008;17:480–491. - PMC - PubMed

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