Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jan 5;102(1):1-7.
doi: 10.1038/sj.bjc.6605457. Epub 2009 Nov 24.

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

M Beloueche-Babari  1 , Y-L Chung, N M S Al-Saffar, M Falck-Miniotis, M O Leach
Affiliations
Review

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

M Beloueche-Babari et al. Br J Cancer. .

Abstract

Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use.

PubMed Disclaimer

Figures

Figure 1
Figure 1
31P-MR spectra showing the effect of the HDAC inhibitor LAQ824 on tumour cell metabolism in vitro (A) and in vivo (B). Metabolites: PC, phosphocholine; GPC, glycerophosphocholine; GPE, glycerophosphoethanolamine; Pi, inorganic phosphate; PMEs, phosphomonoesters; PDEs, phosphodiesters; PCr, phosphocreatine; NTPs, nucleotide triphosphates.
Figure 2
Figure 2
A schematic representation showing links between choline metabolism and some oncogenic signal transduction pathways. Metabolites: CDP-Cho, cytidine diphosphate choline; DAG, diacylglycerol; FAs, fatty acids; G3P, glycerol 3-phosphate; GPC, glycerophosphocholine; Lyso-PtdCho, 1-acyl or 2-acyl-phosphatidylcholine; PA, phosphatidic acid; PtdCho, phosphatidylcholine. Mitogenic signal transduction proteins are shown as black circles and phospholipid metabolic enzymes are shown as white rectangles (modified from Beloueche-Babari et al, 2006).
See this image and copyright information in PMC

References

    1. Aboagye EO, Bhujwalla ZM (1999) Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 59: 80–84 - PubMed
    1. Aboagye EO, Bhujwalla ZM, He Q, Glickson JD (1998) Evaluation of lactate as a 1H nuclear magnetic resonance spectroscopy index for noninvasive prediction and early detection of tumor response to radiation therapy in EMT6 tumors. Radiat Res 150: 38–42 - PubMed
    1. Al-Saffar NM, Troy H, Ramirez de MA, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL (2006) Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res 66: 427–434 - PubMed
    1. Arias-Mendoza F, Payne GS, Zakian KL, Schwarz AJ, Stubbs M, Stoyanova R, Ballon D, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR (2006) In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. NMR Biomed 19: 504–512 - PubMed
    1. Banerji U, de Bono J, Judson I, Kaye S, Workman P (2008) Biomarkers in early clinical trials: the committed and the skeptics. Clin Cancer Res 14: 2512–2514 - PubMed

Publication types

MeSH terms