Lighting up neural networks using a new generation of genetically encoded calcium sensors
- PMID: 19935839
- DOI: 10.1038/nmeth1209-871
Lighting up neural networks using a new generation of genetically encoded calcium sensors
Abstract
Two improved genetically encoded calcium indicators-based on structure-guided sensor design or on precise subcellular targeting to presynaptic boutons-allow single spikes to be detected in genetically defined populations of neurons and synapses in vivo.
Comment on
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A genetically encoded reporter of synaptic activity in vivo.Nat Methods. 2009 Dec;6(12):883-9. doi: 10.1038/nmeth.1399. Epub 2009 Nov 8. Nat Methods. 2009. PMID: 19898484 Free PMC article.
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Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators.Nat Methods. 2009 Dec;6(12):875-81. doi: 10.1038/nmeth.1398. Epub 2009 Nov 8. Nat Methods. 2009. PMID: 19898485 Free PMC article.
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