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Comment
. 2009 Dec;6(12):873-4.
doi: 10.1038/nmeth1209-873.

Use of microRNA sponges to explore tissue-specific microRNA functions in vivo

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Comment

Use of microRNA sponges to explore tissue-specific microRNA functions in vivo

Stephen M Cohen. Nat Methods. 2009 Dec.

Abstract

MicroRNA depletion by sequestration produces flexible hypomorphs that mimic mutants obtained by microRNA gene targeting.

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References

    1. Genetics. 2006 Jun;173(2):769-77 - PubMed
    1. Nat Genet. 2009 May;41(5):614-8 - PubMed
    1. Cell. 2007 Oct 5;131(1):136-45 - PubMed
    1. Curr Biol. 2008 Apr 8;18(7):501-6 - PubMed
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