Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct;93(4):367-73, 360-6.
doi: 10.1590/s0066-782x2009001000009.

Study of vascular reactivity in HIV patients whether or not receiving protease inhibitor

[Article in English, Portuguese, Spanish]
Hamilton Nenrod Pereira Teixeira  1 , Evandro Tinoco Mesquita, Mário Luiz Ribeiro, Anna Ricordi Bazin, Cláudio Tinoco Mesquita, Manuel Pereira Teixeira, Rafael da Cunha Pellegrini, Antonio Claudio Lucas da Nóbrega
Affiliations
Free article

Study of vascular reactivity in HIV patients whether or not receiving protease inhibitor

[Article in English, Portuguese, Spanish]
Hamilton Nenrod Pereira Teixeira et al. Arq Bras Cardiol. 2009 Oct.
Free article

Abstract

Background: A great number of HIV-infected patients using antiretroviral drugs develop endothelial dysfunction and atherothrombosis, which lead to a high medical and social burden. Thus, it is important to identify pathophysiological mechanisms involved with the endothelial function in these patients, so that early intervention can be made to avoid disease progression.

Objective: To evaluate endothelial function using endothelium-dependent and independent vasodilation in HIV-positive patients and in a control group.

Methods: A total of 27 HIV-positive patients and 16 controls were evaluated. Endothelium-dependent (reactive hyperemia) and independent (SL nitroglycerine) vasodilation of the brachial artery was used to evaluate the endothelial function.

Results: HIV-positive patients receiving protease inhibitors (PI) showed significantly lower endothelium-independent vasodilation than the HIV-negative (p=0.020) and HIV-positive without PI (p=0.034) subgroups. The change in brachial artery diameter during active hyperemia was not statistically significant in any subgroup. Multiple linear regression analysis showed that only PI was associated with the relative delta of brachial reactivity to vasodilator in HIV-positive patients at 60s and 90s.

Conclusion: HIV-positive patients receiving PI presented endothelium-independent dysfunction when compared to HIV-positive patients not receiving PI and to the control group.

PubMed Disclaimer

Publication types