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. 2009 Nov 28;15(44):5558-62.
doi: 10.3748/wjg.15.5558.

Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis

Erwin Gäbele  1 , Marcus Mühlbauer, Hartwig Paulo, Monika Johann, Christin Meltzer, Franz Leidl, Norbert Wodarz, Reiner Wiest, Jürgen Schölmerich, Claus Hellerbrand
Affiliations

Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis

Erwin Gäbele et al. World J Gastroenterol. .

Abstract

Aim: To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP).

Methods: MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.

Results: The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis (n = 80), carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%, P = 0.021).

Conclusion: In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP.

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