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. 2010 Jan;17(1):199-201.
doi: 10.1128/CVI.00305-09. Epub 2009 Nov 25.

Long-term observation of subunit vaccine F1-rV270 against Yersinia pestis in mice

Zuyun Wang  1 , Lei Zhou, Zhizhen Qi, Qingwen Zhang, Ruixia Dai, Yonghai Yang, Baizhong Cui, Hu Wang, Ruifu Yang, Xiaoyi Wang
Affiliations

Long-term observation of subunit vaccine F1-rV270 against Yersinia pestis in mice

Zuyun Wang et al. Clin Vaccine Immunol. 2010 Jan.

Abstract

Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after primary immunization.

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Figures

FIG. 1.
FIG. 1.
Development of antibody titers to F1 and rV270 in female mice over a period of 77 days.
FIG. 2.
FIG. 2.
Development of antibody titers to F1 and rV270 in female mice over a period of 147 days.
FIG. 3.
FIG. 3.
Development of antibody titers to F1 and rV270 in female mice over a period of 539 days.
See this image and copyright information in PMC

References

    1. Anderson, G. W., Jr., D. G. Heath, C. R. Bolt, S. L. Welkos, and A. M. Friedlander. 1998. Short- and long-term efficacy of single-dose subunit vaccines against Yersinia pestis in mice. Am. J. Trop. Med. Hyg. 58:793-799. - PubMed
    1. Anisimov, A. P., L. E. Lindler, and G. B. Pier. 2004. Intraspecific diversity of Yersinia pestis. Clin. Microbiol. Rev. 17:434-464. - PMC - PubMed
    1. Bourgeois, C., and C. Tanchot. 2003. CD4 T cells are required for CD8 T cell memory generation. Eur. J. Immunol. 33:3225-3231. - PubMed
    1. Campos, M., and D. L. Godson. 2003. The effectiveness and limitations of immune memory: understanding protective immune responses. Int. J. Parasitol. 33:655-661. - PubMed
    1. Glynn, A., L. C. Freytag, and J. D. Clements. 2005. Effect of homologous and heterologous prime-boost on the immune response to recombinant plague antigens. Vaccine 23:1957-1965. - PubMed

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