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. 2010 Oct;20(10):642-4.
doi: 10.1097/FPC.0b013e32833433b6.

VKORC1 pharmacogenomics summary

Ryan P Owen  1 , Li Gong, Hersh Sagreiya, Teri E Klein, Russ B Altman
Affiliations

VKORC1 pharmacogenomics summary

Ryan P Owen et al. Pharmacogenet Genomics. 2010 Oct.
No abstract available

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References

    1. Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004;427:537–541. - PubMed
    1. Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW. Identification of the gene for vitamin K epoxide reductase. Nature. 2004;427:541–544. - PubMed
    1. Oldenburg J, Bevans CG, Muller CR, Watzka M. Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. Antioxid Redox Signal. 2006;8:347–353. - PubMed
    1. Wajih N, Sane DC, Hutson SM, Wallin R. Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system. J Biol Chem. 2005;280:10540–10547. - PubMed
    1. Stafford DW. The vitamin K cycle. J Thromb Haemost. 2005;3:1873–1878. - PubMed

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