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. 2009 Nov 27:7:137.
doi: 10.1186/1477-7827-7-137.

A retrospective study on IVF outcome in euthyroid patients with anti-thyroid antibodies: effects of levothyroxine, acetyl-salicylic acid and prednisolone adjuvant treatments

Alberto Revelli  1 , Simona Casano, Luisa Delle Piane, Giuseppina Grassi, Gianluca Gennarelli, Daniela Guidetti, Marco Massobrio
Affiliations

A retrospective study on IVF outcome in euthyroid patients with anti-thyroid antibodies: effects of levothyroxine, acetyl-salicylic acid and prednisolone adjuvant treatments

Alberto Revelli et al. Reprod Biol Endocrinol. .

Abstract

Background: Anti-thyroid antibodies (ATA), even if not associated with thyroid dysfunction, are suspected to cause poorer outcome of in vitro fertilization (IVF).

Methods: We retrospectively analyzed: (a) the prevalence of ATA in euthyroid infertile women, (b) IVF outcome in euthyroid, ATA+ patients, and (c) the effect of adjuvant treatments (levothyroxine alone or associated with acetylsalicylic acid and prednisolone) on IVF results in ATA+ patients. One hundred twenty-nine euthyroid, ATA+ women undergoing IVF were compared with 200 matched, ATA-controls. During IVF cycle, 38 ATA+ patients did not take any adjuvant treatment, 55 received levothyroxin (LT), and 38 received LT +acetylsalicylic acid (ASA)+prednisolone (P).

Results: The prevalence of ATA among euthyroid, infertile patients was 10.5%, similar to the one reported in euthyroid women between 18 and 45 years. ATA+ patients who did not receive any adjuvant treatment showed significantly poorer ovarian responsiveness to stimulation and IVF results than controls. ATA+ patients receiving LT responded better to ovarian stimulation, but had IVF results as poor as untreated ATA+ women. Patients receiving LT+ASA+P had significantly higher pregnancy and implantation rates than untreated ATA+ patients (PR/ET 25.6% and IR 17.7% vs. PR/ET 7.5% and IR 4.7%, respectively), and overall IVF results comparable to patients without ATA (PR/ET 32.8% and IR 19%).

Conclusion: These observations suggest that euthyroid ATA+ patients undergoing IVF could have better outcome if given LT+ASA+P as adjuvant treatment. This hypothesis must be verified in further randomized, prospective studies.

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References

    1. Poppe K, Velkeniers B, Glinoert D. Thyroid disease and female reproduction. Clin Endocrinol. 2007;66:309–391. doi: 10.1111/j.1365-2265.2007.02752.x. - DOI - PubMed
    1. Poppe K, Velkeniers B, Glinoer D. The role of thyroid autoimmunity in infertility and pregnancy. Natl Clin Pract Endocrinol Metab. 2008;4:394–405. doi: 10.1038/ncpendmet0846. - DOI - PubMed
    1. Poppe K, Glinoer D, Van Steirteghem A, Tournaye H, Devroey P, Schiettecatte J, Velkeniers B. Thyroid dysfunction and autoimmunity in infertile women. Thyroid. 2002;12:997–1001. doi: 10.1089/105072502320908330. - DOI - PubMed
    1. Sinaii N, Cleary SD, Ballweg ML, Nieman LK, Stratton P. High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Hum Reprod. 2002;17:2715–2724. doi: 10.1093/humrep/17.10.2715. - DOI - PubMed
    1. Belvisi L, Bombelli F, Sironi L, Doldi N. Organan-specific autoimmunity in patients with premature ovarian failure. J Endocrinol Invest. 1993;16:889–892. - PubMed

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