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Review
. 2010 Feb;62(2):300-7.
doi: 10.1016/j.jaad.2009.02.035. Epub 2009 Nov 26.

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

Rachel H Gormley  1 , Stephen D Hess, Dipti Anand, Jacqueline Junkins-Hopkins, Alain H Rook, Ellen J Kim
Affiliations
Review

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

Rachel H Gormley et al. J Am Acad Dermatol. 2010 Feb.

Abstract

Cutaneous T-cell lymphomas most commonly have a CD4(+) memory T-cell phenotype with relatively indolent course, but may in rare cases present with a CD8(+) cytotoxic phenotype exhibiting strikingly more aggressive clinical behavior. We present two cases of the clinically aggressive subtype of primary cutaneous epidermotropic CD8(+) cutaneous T-cell lymphoma and review the current literature, clinical behavior, and recommendations for treatment distinct from that of more common CD4(+) variants of cutaneous T-cell lymphoma.

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