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. 2010 Feb;45(2):738-44.
doi: 10.1016/j.ejmech.2009.11.021. Epub 2009 Nov 18.

Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

Saleh I Alqasoumi  1 , Areej M Al-Taweel, Ahmed M Alafeefy, Eman Noaman, Mostafa M Ghorab
Affiliations

Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

Saleh I Alqasoumi et al. Eur J Med Chem. 2010 Feb.

Abstract

Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24, 19 and 12 showed higher activity with IC(50) values (5.5, 6.9, 7 microg/ml) when compared with Doxorubicin as a reference drug (IC(50) value 38 microg/ml).

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