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Comment
. 2009 Dec 15;66(12):1072-4.
doi: 10.1016/j.biopsych.2009.09.023.

Imbalance of approach and avoidance: the yin and yang of anxiety disorders

Murray B Stein  1 , Martin P Paulus
Affiliations
Comment

Imbalance of approach and avoidance: the yin and yang of anxiety disorders

Murray B Stein et al. Biol Psychiatry. .
No abstract available

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Figures

Figure 1
Figure 1
Conceptual representation of the impact of traumatic stress on altering homeostatic steady state in PTSD.
Figure 2
Figure 2
This figure attempts to summarize how one can begin to integrate (1) specific neural systems (2) behavioral processes, and (3) neurotransmitter systems in describing the pathology observed in PTSD. Specifically, given an altered imbalance of approach-avoidance systems, which could be related to modulating neurotransmitter systems, individuals find themselves processing approach avoidance situations differently using some of the key neural substrates, i.e., amygdala, ventral striatum, insula, and medial prefrontal cortex, to adjust to an altered homeostatic steady state.
See this image and copyright information in PMC

Comment on

References

    1. Milad MR, Pitman RK, Ellies CB, Gold AL, Shin LM, Lasko NB, Zeidan MA, Handwerger K, Orr SP, Rauch SL. Neurobiological basis of failure to recall extinction memory in Posttraumatic Stress Disorder. Biological Psychiatry. 2009 in press. - PMC - PubMed
    1. Ravindran LN, Stein MB. Pharmacotherapy of PTSD: premises, principles, and priorities. Brain Res. EPub ahead of print. - PMC - PubMed
    1. Elman I, Lowen S, Frederick BB, Chi W, Becerra L, Pitman RK. Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in Posttraumatic Stress Disorder. Biological Psychiatry. 2009 in press. - PMC - PubMed
    1. Sailer U, Robinson S, Fischmeister FP, Konig D, Oppenauer C, Lueger-Schuster B, Moser E, Kryspin-Exner I, Bauer H. Altered reward processing in the nucleus accumbens and mesial prefrontal cortex of patients with posttraumatic stress disorder. Neuropsychologia. 2008;46(11):2836–2844. - PubMed
    1. Berlyne DE. Conflict, arousal, and curiosity. New York: McGraw-Hill; 1960.