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Review
. 2009 Dec;36(4):859-80, vii.
doi: 10.1016/j.clp.2009.07.013.

Neuroprotection in the newborn infant

Fernando F Gonzalez  1 , Donna M Ferriero
Affiliations
Review

Neuroprotection in the newborn infant

Fernando F Gonzalez et al. Clin Perinatol. 2009 Dec.

Abstract

Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.

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