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. 2010 Jan-Feb;31(1):9-13.
doi: 10.1016/j.amjoto.2008.08.013. Epub 2009 Mar 13.

The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

Yeo-Hoon Yoon  1 , Jae Yong Park, Yong Ho Park
Affiliations

The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

Yeo-Hoon Yoon et al. Am J Otolaryngol. 2010 Jan-Feb.

Abstract

Objective: The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model.

Study design: This is a randomized, controlled animal study.

Subjects and methods: Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination.

Results: External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration.

Conclusion: This study suggests that MMC can be helpful in preventing EAC fibrosis after injury.

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