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Review
. 2010 Mar;125(3):205-9.
doi: 10.1016/j.thromres.2009.11.004. Epub 2009 Nov 27.

The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes

Lea M Beaulieu  1 , Jane E Freedman
Affiliations
Review

The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes

Lea M Beaulieu et al. Thromb Res. 2010 Mar.

Abstract

Platelets have been extensively studied as hemostatic regulators, stopping uncontrolled flow of blood from an injured vessel and allowing for repair. However, multiple studies have shown that platelets can interact with bacterial proteins, particularly seen during sepsis and inflammation. Immune cells recognize pathogens through Toll-like Receptors (TLRs). These same receptors allow platelets to recognize bacterial proteins and regulate platelet immunity and function. This review examines the TLRs expressed on platelets and megakaryocytes and how these receptors affect the function of these cells. Through TLRs, platelets go beyond hemostatic regulation and play a pivotal role in inflammation and infection.

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Figures

Figure 1
Figure 1
Summary of the TLRs shown to be expressed on platelets and the effects they have on platelet function.
See this image and copyright information in PMC

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