Pushing and pulling: microtubules mediate meiotic pairing and synapsis
- PMID: 19945372
- DOI: 10.1016/j.cell.2009.11.013
Pushing and pulling: microtubules mediate meiotic pairing and synapsis
Abstract
Meiotic pairing in the nematode Caenorhabditis elegans is facilitated by chromosomal sites known as pairing centers that are tethered to the nuclear envelope. Sato et al. (2009) and Penkner et al. (2009) provide insight into how proteins linking pairing centers and the microtubule cytoskeleton mediate homolog pairing and restrict synapsis to homologous pairs of chromosomes.
Comment on
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Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.Cell. 2009 Nov 25;139(5):920-33. doi: 10.1016/j.cell.2009.10.045. Epub 2009 Nov 12. Cell. 2009. PMID: 19913286
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Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis.Cell. 2009 Nov 25;139(5):907-19. doi: 10.1016/j.cell.2009.10.039. Epub 2009 Nov 12. Cell. 2009. PMID: 19913287 Free PMC article.
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