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Comment
. 2009 Nov 25;139(5):865-7.
doi: 10.1016/j.cell.2009.11.009.

X chromosome inactivation: when dosage counts

Elphège P Nora  1 , Edith Heard
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X chromosome inactivation: when dosage counts

Elphège P Nora et al. Cell. .
Free article

Abstract

How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.

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