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. 2010 Jan 2;86(1-2):59-65.
doi: 10.1016/j.lfs.2009.11.011. Epub 2009 Nov 27.

Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice

Mai Akiho  1 , Hiroyuki Nakashima, Munehiro Sakata, Yuka Yamasa, Akihiko Yamaguchi, Kunihiro Sakuma
Affiliations

Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice

Mai Akiho et al. Life Sci. .

Abstract

Aim: We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice.

Main methods: We performed immunofluorescence of both Notch-1 and the Notch-1-linking molecules.

Key findings: Immunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2-6. We observed clear co-localization between Notch-1 and myogenin (4.9+/-1.3%) in the hypertrophied muscle at 4days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1+/-1.2%).

Significance: Notch-1 may play an important role in the maintenance of quiescent satellite cells.

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