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. 2010 Jan;8(1):8-14.
doi: 10.1038/nrmicro2266.

The molecular basis of the host response to lipopolysaccharide

Clare E Bryant  1 , David R Spring, Monique Gangloff, Nicholas J Gay
Affiliations

The molecular basis of the host response to lipopolysaccharide

Clare E Bryant et al. Nat Rev Microbiol. 2010 Jan.

Abstract

Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.

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