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. 2009:2009:476897.
doi: 10.1155/2009/476897. Epub 2009 Jul 28.

Oral contraceptives after myomectomy: a short term trial

Stefano Luisi  1 , Valentina Ciani, Massimo Gabbanini, Sofia Sollazzi, Michela Torricelli, Francesco Calonaci, Felice Petraglia
Affiliations

Oral contraceptives after myomectomy: a short term trial

Stefano Luisi et al. Int J Endocrinol. 2009.

Abstract

Following myomectomy the rate of fertility is restored and pregnancy may be attempted with a good outcome. In the present study a 3 month treatment with OCs in a group of women after a myomectomy was evaluated. The drug compliance and side effects, the benefits of OC in order to reduce symptoms, to increase post-surgical hemoglobin levels and to avoid an early pregnancy after myomectomy were analyzed. A group of women (n = 55) each with myoma >/=5 cm was recruited: they presented menorrhagia, pelvic pain, dyspareunia and dysmenorrhae. After laparotomic myomectomy the women were divided into 3 groups. Group 1: women (n = 16) treated with pill A (15 mcg of ethynilestradiol + 60 mcg of gestodene); group 2: women (n = 23) treated with pill B (20 mcg of ethynilestradiol + 100 mcg of levonorgestrel); group 3: women (n = 16) treated with a placebo (oral calcium). After three months from myomectomy and treatment patients in each group reported a reduced menorrhagia, dismenorrhea and pelvic pain. Serum haemoglobin levels increased in all women (P < .05). No pregnancy occurred in any group and the compliance was good. A post surgery treatment by using oral contraceptives guarentees pregnancy prevention, associated with reduction of pain, and improvement of haematologic conditions.

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Figures

Figure 1
Figure 1
Serum haemoglobin concentration after treatment in the three groups. Group 1: women treated with 15 mcg of ethynilestradiol + 60 mcg of gestodene; group 2: women treated with 20 mcg of ethynilestradiol + 100 mcg of levonorgestrel; group 3: women treated with a placebo. * = P < .05.
Figure 2
Figure 2
Improvement of symptoms (dysmenorrhoea, pelvic pain, menorrhagia) after myomectomy and OCs use.
See this image and copyright information in PMC

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