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Review
. 2009 Sep;15(9):840-3.

[TGF-beta/Smad in prostate cancer: an update]

[Article in Chinese]
Ji Zha  1 , Yu-feng Huang
Affiliations
  • PMID: 19947572
Review

[TGF-beta/Smad in prostate cancer: an update]

[Article in Chinese]
Ji Zha et al. Zhonghua Nan Ke Xue. 2009 Sep.

Abstract

Tumorigenesis and cancer progression are closely associated with the transforming growth factor-beta (TGF-beta) and its downstream component Smad. The TGF-beta/Smad signaling pathway, which is activated in prostate cancer, has a regulatory effect on cell adhesion, the actin filament system and cell cycle, as well as the expression of specific genes. Meanwhile, other protein signals such as MAPK and PI3K/Akt/mTOR and some genes may act on the expression of the TGF-beta/Smad pathway. This article updates recent researches on the expression, action and regulatory effect of the TGF-beta/Smad signaling pathway in prostate cancer.

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