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Comment
. 2009 Dec 1;19(22):R1032-4.
doi: 10.1016/j.cub.2009.10.013.

Mitosis: too much of a good thing (can be bad)

Alexey Khodjakov  1 , Conly L Rieder
Affiliations
Comment

Mitosis: too much of a good thing (can be bad)

Alexey Khodjakov et al. Curr Biol. .

Abstract

Recent studies reveal that the precise regulation of microtubule dynamics is essential for an error-free mitosis. Kinetochore microtubule attachments that are too stable increase the rate of chromosome mis-segregation, a leading cause of chromosomal instability in tumors.

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Figures

Figure 1
Figure 1
(A) Schematic of a mitotic cell with all kinetochores already attached to the spindle. Chromosomes `A1' and `A2' are amphitelic, `M' is merotelic, and `S' is syntelic. (B) If anaphase is initiated in the presence of erroneously attached kinetochores, both daughter cells become aneuploid. In this example, the cell on the left inherits both chromatids of the syntelic chromosome (s). In contrast, both chromatids of the merotelic chromosome (m) segregate into the right-hand cell. Only amphitelic attachment results in proper chromosome segregation (a1 and a2).
See this image and copyright information in PMC

Comment on

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