[Lipid composition of circulating lipoproteins in various types of hyperlipoproteinemia (author's transl)]

Abstract

By means of simple and selective precipitation methods with polyanions, three lipoprotein fractions rich in HDL (F1), LDL (F2) and VLDL (F3) were isolated from serum of normal subjects, of normolipemic patients with atherosclerotic disease and of patients with type IIA, IIB or IV hyperlipoproteinemia. Cholesterol content was used to quantify lipoprotein fractions and to measure relative triglycerides abundance (cholesterol/triglyceride ratio and regression coefficients). Findings in the atheroscerotic patients without hyperlipoproteinemia resembled those of the controls. No correlation between cholesterol and triglycerides was obtained in F1 of the various groups. However, a significant relation was established in F2 and the relative content of triglycerides was increased progressively from type IIA, through type IIB to type IV. In all types of hyperlipoproteinemia comparable relationships were found in F3 mainly containing VLDL, the precursor of LDL. In fractions F2 and F3, types IIB and IV were clearly distinguishable from type IIA.