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Meta-Analysis
. 2010 Feb;39(2):200-7.
doi: 10.1016/j.ejvs.2009.10.014. Epub 2009 Nov 30.

Diabetes and the abdominal aortic aneurysm

S Shantikumar  1 , R Ajjan, K E Porter, D J A Scott
Affiliations
Free article
Meta-Analysis

Diabetes and the abdominal aortic aneurysm

S Shantikumar et al. Eur J Vasc Endovasc Surg. 2010 Feb.
Free article

Abstract

Objective: The aim of this review is to delineate the association between abdominal aortic aneurysms (AAAs) and diabetes mellitus. Mechanisms for the underlying association are then discussed.

Methods: A systematic review of the English-language literature using PubMed, EMBASE and Cochrane databases was undertaken up to September 2009. Studies reporting appropriate prevalence data were identified and a meta-analysis performed.

Results: Eleven studies were identified. The prevalence of diabetes mellitus in studied patients with AAA ranged from 6% to 14%. The prevalence of diabetes in control patients without AAA ranged from 17% to 36%. Pooled analysis suggested a reduced rate of diabetes amongst people with AAA compared to those without (OR 0.65, 0.60-0.70, p<0.001).

Conclusions: Studies so far suggest a protective role for diabetes on the development of AAA. Further research is required to demarcate the underlying mechanisms for this possible association.

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