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Comparative Study
. 1991 Jan;50(1):57-8.
doi: 10.1136/ard.50.1.57.

Degradation of human cartilage by synovial fluid but not cytokines in vitro

A P Hollander  1 , R M Atkins, D M Eastwood, P A Dieppe, C J Elson
Affiliations
Comparative Study

Degradation of human cartilage by synovial fluid but not cytokines in vitro

A P Hollander et al. Ann Rheum Dis. 1991 Jan.

Abstract

Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.

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Comment in

  • Degradation of human cartilage by cytokines in vitro.
    Nietfeld JJ, Wilbrink B, Huber-Bruning O, Bijlsma JW, Nietfeld JJ, Den Otter W. Nietfeld JJ, et al. Ann Rheum Dis. 1991 Dec;50(12):967. doi: 10.1136/ard.50.12.967-b. Ann Rheum Dis. 1991. PMID: 1768174 Free PMC article. No abstract available.

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