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. 2010 Feb;54(2):963-5.
doi: 10.1128/AAC.01215-09. Epub 2009 Nov 30.

In vitro adsorption of gentamicin and netilmicin by polyacrylonitrile and polyamide hemofiltration filters

Philip K N Lam  1 , Qi Tian, Margaret Ip, Charles D Gomersall
Affiliations

In vitro adsorption of gentamicin and netilmicin by polyacrylonitrile and polyamide hemofiltration filters

Philip K N Lam et al. Antimicrob Agents Chemother. 2010 Feb.

Abstract

Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro. Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less.

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Figures

FIG. 1.
FIG. 1.
Cumulative adsorption of gentamicin by hemofilters against time. Data are shown as median and range. §, P < 0.05 versus polyamide; ns, no significant difference versus previous time point; ^, P < 0.05 versus previous time point.
FIG. 2.
FIG. 2.
Cumulative adsorption of netilmicin by hemofilters against time. Data are shown as median and range. §, P < 0.05 versus polyamide; ns, no significant difference versus previous time point; ^, P < 0.05 versus previous time point.
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