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. 2010 Feb;54(2):945-9.
doi: 10.1128/AAC.01316-09. Epub 2009 Nov 30.

Detection and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates in Canada: results from the Canadian Nosocomial Infection Surveillance Program, 1995-2006

Heather J Adam  1 , Lisa Louie, Christine Watt, Denise Gravel, Elizabeth Bryce, Mark Loeb, Anne Matlow, Allison McGeer, Michael R Mulvey, Andrew E Simor; Canadian Nosocomial Infection Surveillance Program
Collaborators, Affiliations

Detection and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates in Canada: results from the Canadian Nosocomial Infection Surveillance Program, 1995-2006

Heather J Adam et al. Antimicrob Agents Chemother. 2010 Feb.

Abstract

We describe the epidemiology of heterogeneously resistant Staphylococcus aureus (hVISA) identified in Canadian hospitals between 1995 and 2006. hVISA isolates were confirmed by the population analysis profiling-area under the curve method. Only 25 hVISA isolates (1.3% of all isolates) were detected. hVISA isolates were more likely to have been health care associated (odds ratio [OR], 5.1; 95% confidence interval [CI], 1.9 to 14.2) and to have been recovered from patients hospitalized in central Canada (OR, 3.0; 95% CI, 1.2 to 7.4). There has been no evidence of vancomycin "MIC creep" in Canadian strains of methicillin (meticillin)-resistant S. aureus, and hVISA strains are currently uncommon.

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