Review
doi: 10.1111/j.1742-4658.2009.07464.x.
Epub 2009 Nov 27.
Human telomeric G-quadruplex: structures of DNA and RNA sequences
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- PMID: 19951353
- DOI: 10.1111/j.1742-4658.2009.07464.x
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Review
Human telomeric G-quadruplex: structures of DNA and RNA sequences
FEBS J.
2010 Mar.
Free article
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.
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