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. 2009 Nov 30;1(11):113.
doi: 10.1186/gm113.

Secretome: clues into pathogen infection and clinical applications

Shoba Ranganathan  1 , Gagan Garg
Affiliations

Secretome: clues into pathogen infection and clinical applications

Shoba Ranganathan et al. Genome Med. .

Abstract

The secretome encompasses the complete set of gene products secreted by a cell. Recent studies on secretome analysis reveal that secretory proteins play an important role in pathogen infection and host-pathogen interactions. Excretory/secretory proteins of pathogens change the host cell environment by suppressing the immune system, to aid the proliferation of infection. Identifying secretory proteins involved in pathogen infection will lead to the discovery of potential drug targets and biomarkers for diagnostic applications.

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Figures

Figure 1
Figure 1
Overview of the EST2Secretome workflow. Pathogen EST sequences are analyzed by EST2Secretome to predict excretory/secretory (ES) proteins, which are functionally annotated in terms of InterPro domains, KEGG pathways, interaction partners and homologues from pathogenic, non-pathogenic and host databases.
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