The need for large-scale randomized evidence without undue emphasis on small trials, meta-analyses, or subgroup analyses

Affiliations

¹ Department of Clinical Science and Medical Education, Charles E. Schmidt College of Biomedical Science and Center of Excellence, Florida Atlantic University, Boca Raton, FL 33431, USA. chenneke@fau.edu

Charles H Hennekens et al. JAMA. 2009.

. 2009 Dec 2;302(21):2361-2.

doi: 10.1001/jama.2009.1756.

¹ Department of Clinical Science and Medical Education, Charles E. Schmidt College of Biomedical Science and Center of Excellence, Florida Atlantic University, Boca Raton, FL 33431, USA. chenneke@fau.edu

No abstract available

Comment in

Evidence from randomized controlled trials, meta-analyses, and subgroup analyses.
Sacristán JA. Sacristán JA. JAMA. 2010 Apr 7;303(13):1253-4; author reply 1254-5. doi: 10.1001/jama.2010.365. JAMA. 2010. PMID: 20371780 No abstract available.
Evidence from randomized controlled trials, meta-analyses, and subgroup analyses.
Vosk A. Vosk A. JAMA. 2010 Apr 7;303(13):1253; author reply 1254-5. doi: 10.1001/jama.2010.364. JAMA. 2010. PMID: 20371781 No abstract available.
Evidence from randomized controlled trials, meta-analyses, and subgroup analyses.
Bolland MJ, Grey A, Reid IR. Bolland MJ, et al. JAMA. 2010 Apr 7;303(13):1254; author reply 1254-5. doi: 10.1001/jama.2010.366. JAMA. 2010. PMID: 20371782 No abstract available.