The need for large-scale randomized evidence without undue emphasis on small trials, meta-analyses, or subgroup analyses

Affiliations

¹ Department of Clinical Science and Medical Education, Charles E. Schmidt College of Biomedical Science and Center of Excellence, Florida Atlantic University, Boca Raton, FL 33431, USA. chenneke@fau.edu

Charles H Hennekens et al. JAMA. 2009.

. 2009 Dec 2;302(21):2361-2.

doi: 10.1001/jama.2009.1756.

¹ Department of Clinical Science and Medical Education, Charles E. Schmidt College of Biomedical Science and Center of Excellence, Florida Atlantic University, Boca Raton, FL 33431, USA. chenneke@fau.edu

No abstract available

Comment in

Evidence from randomized controlled trials, meta-analyses, and subgroup analyses.
Sacristán JA. Sacristán JA. JAMA. 2010 Apr 7;303(13):1253-4; author reply 1254-5. doi: 10.1001/jama.2010.365. JAMA. 2010. PMID: 20371780 No abstract available.
Evidence from randomized controlled trials, meta-analyses, and subgroup analyses.
Vosk A. Vosk A. JAMA. 2010 Apr 7;303(13):1253; author reply 1254-5. doi: 10.1001/jama.2010.364. JAMA. 2010. PMID: 20371781 No abstract available.
Evidence from randomized controlled trials, meta-analyses, and subgroup analyses.
Bolland MJ, Grey A, Reid IR. Bolland MJ, et al. JAMA. 2010 Apr 7;303(13):1254; author reply 1254-5. doi: 10.1001/jama.2010.366. JAMA. 2010. PMID: 20371782 No abstract available.

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Nicholson LJ. Nicholson LJ. Curr Gastroenterol Rep. 2011 Aug;13(4):336-43. doi: 10.1007/s11894-011-0198-4. Curr Gastroenterol Rep. 2011. PMID: 21607652 Review.
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Fonagy P. Fonagy P. World Psychiatry. 2015 Jun;14(2):137-50. doi: 10.1002/wps.20235. World Psychiatry. 2015. PMID: 26043322 Free PMC article.
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Sanderson M, Levine RS, Fadden MK, Kilbourne B, Pisu M, Cain V, Husaini BA, Langston M, Gittner L, Zoorob R, Rust GS, Hennekens CH. Sanderson M, et al. Am J Med. 2015 Dec;128(12):1362.e7-14. doi: 10.1016/j.amjmed.2015.06.032. Epub 2015 Jul 11. Am J Med. 2015. PMID: 26169884 Free PMC article.
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