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. 2010 Jan 2;24(1):153-5.
doi: 10.1097/QAD.0b013e32832326d8.

Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission

Carey Farquhar  1 , Dorothy Mbori-Ngacha, Julie Overbaugh, Dalton Wamalwa, Jennifer Harris, Rose Bosire, Grace John-Stewart
Affiliations

Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission

Carey Farquhar et al. AIDS. .

Abstract

HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2-5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.

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