Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Dec;124(6 Suppl):e327-e339.
doi: 10.1097/PRS.0b013e3181bf8413.

Composite tissue allotransplantation

Maria Z Siemionow  1 , Yalcin Kulahci, Mehmet Bozkurt
Affiliations
Review

Composite tissue allotransplantation

Maria Z Siemionow et al. Plast Reconstr Surg. 2009 Dec.

Abstract

Recently, composite tissue allotransplantation was introduced as a potential clinical treatment for complex reconstructive procedures, including tumor ablative operations, traumatic injuries, and extensive tissue loss secondary to burns. Composite tissue allotransplantations consist of heterogeneous tissues including skin, fat, muscle, nerves, lymph nodes, bone, cartilage, ligaments, and bone marrow, all presenting with different antigenicity. Thus, composite tissue allotransplantations are considered to elicit a stronger response compared with solid organ transplants. This article outlines different experimental models and current clinical applications of composite tissue allotransplantation.

PubMed Disclaimer

References

    1. Gordon CR, Nazzal J, Lozano-Calderan SA, et al. From experimental rat hindlimb to clinical face composite tissue allotransplantation: Historical background and current status. Microsurgery 2006;26:566–572.
    1. Gorantla V, Maldonado C, Frank J, Barker JH. Composite tissue allotransplantation (CTA): Current status and future insights. Eur J Trauma 2001;27:267–274.
    1. Siemionow M, Ozer K. Advances in composite tissue allograft transplantation as related to the hand and upper extremity. J Hand Surg (Am.) 2002;27:565–580.
    1. Siemionow M, Papay F, Kulahci Y, et al. Coronal-posterior approach for face/scalp flap harvesting in preparation for face transplantation. J Reconstr Microsurg. 2006;22:399–405.
    1. Siemionow M, Bozkurt M, Kulahci Y. Current status of composite tissue allotransplantation. Handchir Mikrochir Plast Chir. 2007;39:145–155.

LinkOut - more resources