Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Apr;30(4):857-63.
doi: 10.1038/jcbfm.2009.250. Epub 2009 Dec 2.

Interleukin-6 release after carotid artery stenting and periprocedural new ischemic lesions

Yuko Abe  1 , Manabu Sakaguchi, Shigetaka Furukado, Toshiyuki Fujinaka, Saburo Sakoda, Toshiki Yoshimine, Kazuo Kitagawa
Affiliations

Interleukin-6 release after carotid artery stenting and periprocedural new ischemic lesions

Yuko Abe et al. J Cereb Blood Flow Metab. 2010 Apr.

Abstract

Carotid artery stenting (CAS) is currently a standard procedure to treat severe carotid artery stenosis. This procedure causes mechanical plaque rupture, potentially releasing soluble factors into the circulating blood. The purpose of this study is to clarify whether inflammation factors are released from an atherosclerotic plaque after CAS and whether local release of inflammation factors is associated with periprocedural new ischemic lesions. The study consisted of 35 patients with 40 severely stenotic carotid arteries who underwent CAS. Blood samples were obtained from the aorta before the procedure and from the carotid plaque site just after the procedure. Blood levels of interleukin-6 (IL-6), interleukin-18, matrix metalloproteinase (MMP)-2, and tissue inhibitor of MMP-1 were determined. Diffusion-weighted magnetic resonance imaging was performed before and after the procedure. Among inflammatory markers, IL-6 levels markedly increased at the plaque site in comparison to those at the aorta (P<0.001). The IL-6 levels in the local samples were significantly higher in symptomatic lesions than those in asymptomatic lesions. More importantly, higher local IL-6 levels were associated with the appearance of new ischemic lesions (P=0.003). The association remained significant (P=0.030) after controlling for potential risk factors for CAS. Association of local IL-6 levels and periprocedural new ischemic lesions suggests that massive release from the plaque and entry into the cerebral circulation of IL-6 might be one of important factors on periprocedural complications related to CAS.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) A schematic drawing of aortic and local sampling during carotid artery stenting and aspiration. ICA, internal carotid artery; ECA, external carotid artery. (B) Representative DWI-MRI imaging after CAS. New ischemic lesions are shown with white arrows.
Figure 2
Figure 2
Aortic (white bars) and local (shaded bars) levels of IL-6, IL-18, MMP-2, and TIMP-1. Medians and 10th, 25th, 75th, and 90th percentiles are shown.
Figure 3
Figure 3
Aortic (white bars) and local (shaded bars) levels of IL-6 in symptomatic and asymptomatic vessels. Medians and 10th, 25th, 75th, and 90th percentiles are shown.
See this image and copyright information in PMC

References

    1. Blankenberg S, Luc G, Ducimetière P, Arveiler D, Ferrières J, Amouyel P, Evans A, Cambien F, PRIME Study Group Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Circulation. 2003;108:2453–2459. - PubMed
    1. Bond R, Rerkasem K, Rothwell PM. Systematic review of the risks of carotid endarterectomy in relation to the clinical indication for and timing of surgery. Stroke. 2003;34:2290–2303. - PubMed
    1. Cavusoglu E, Ruwende C, Chopra V, Yanamadala S, Eng C, Clark LT, Pinsky DJ, Marmur JD. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an independent predictor of all-causemortality, cardiac mortality, and myocardial infarction. Am Heart J. 2006;151:1101.e1101–1101.e1108. - PubMed
    1. Choudhary S, Higgins CL, Chen IY, Reardon M, Lawrie G, Vick GW, 3rd, Karmonik C, Via DP, Morrisett JD. Quantitation and localization of matrix metalloproteinases and their inhibitors in human carotid endarterectomy tissues. Arterioscler Thromb Vasc Biol. 2006;26:2351–2358. - PubMed
    1. Goodney PP, Schermerhorn ML, Powell RJ. Current status of carotid artery stenting. J Vasc Surg. 2006;43:406–411. - PubMed

Publication types

MeSH terms