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. 2009 Dec 1;34(23):3746-8.
doi: 10.1364/OL.34.003746.

Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy

Nienke Bosschaart  1 , Maurice C G Aalders, Dirk J Faber, Jelmer J A Weda, Martin J C van Gemert, Ton G van Leeuwen
Affiliations

Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy

Nienke Bosschaart et al. Opt Lett. .

Abstract

Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/-0.5 mm(-1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations.

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