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. 1991 Feb 11;279(1):55-7.
doi: 10.1016/0014-5793(91)80249-3.

The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients

M V Aksenova  1 , G S Burbaeva, K V Kandror, D V Kapkov, A S Stepanov
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Free article

The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients

M V Aksenova et al. FEBS Lett. .
Free article

Abstract

The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.

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