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. 2009 Nov;26(8):589-96.
doi: 10.3109/08880010903271689.

Peripheral arterial tonometry in assessing endothelial dysfunction in pediatric sickle cell disease

Krupa M Sivamurthy  1 , Carlton Dampier, MaryLou MacDermott, Meier Maureen, Michele Cahill, Lewis L Hsu
Affiliations

Peripheral arterial tonometry in assessing endothelial dysfunction in pediatric sickle cell disease

Krupa M Sivamurthy et al. Pediatr Hematol Oncol. 2009 Nov.

Abstract

Background: SCD is characterized by hemolysis and oxidative stress, resulting in endothelial dysfunction (EDF). Peripheral arterial tonometry (PAT), a noninvasive technology for measuring EDF, utilizes reactive hyperemia following mini-ischemic stress (reactive hyperemia index or RHI).

Methods: The authors studied PAT in 36 SCD children to determine the influence of hemoglobin genotype and treatment on EDF.

Results and conclusions: Blunted RHI was seen in the majority of children with SCD, especially with increased symptomatology (1.53 and 1.71; p value .032). RHI was not normal in children on chronic transfusion or hydroxyurea. RHI correlated with reticulocyte fraction (Spearman r = -.47, p = .037). PAT merits further exploration as a measure of EDF in SCD.

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