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. 2009 Sep;30(9):592-5.

[Circulating galactomannan screening for early diagnosis and treatment of invasive aspergillosis]

[Article in Chinese]
Jia-feng Yao  1 , Dong Su, Yong Huang, Ping Zhang, Qing-song Lin, Zhi-yong Wang, Si-zhou Feng, Ming-zhe Han
Affiliations
  • PMID: 19954616

[Circulating galactomannan screening for early diagnosis and treatment of invasive aspergillosis]

[Article in Chinese]
Jia-feng Yao et al. Zhonghua Xue Ye Xue Za Zhi. 2009 Sep.

Abstract

Objective: To explore the value of circulating galactomannan (GM) screening for early diagnosis and treatment monitoring of invasive aspergillosis (IA).

Methods: Serum samples from 141 IA patients for the detection of GM by Platelia Aspergillus (Bia-Rad) were collected before and after systematic anti-fungal therapy.

Results: (1) An increase in the clinical diagnosis rate of IA was obtained on the result of GM detection. The GM positivity appeared (10+/-4.1) (8-15) d before positive sputum culture, while (12.6+/-5.7) (6-22) d before the CT positive image. (2) Among the 62 patients with consecutive serum samples, 50 were success in treatment and 12 died. A progressive decrease of GM level was found in the former group, while the rising antigen titres were found in the latter.

Conclusion: Compared with other diagnostic test, GM test has an obvious advantage of higher positivity and earlier result. The anti-fungal effectiveness can be estimated by dynamic detection of serum GM.

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