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Review
. 2010 Apr;162(4):643-52.
doi: 10.1530/EJE-09-0850. Epub 2009 Dec 2.

Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

Konstantinos A Toulis  1 , Dimitrios G Goulis, Christos A Venetis, Efstratios M Kolibianakis, Roberto Negro, Basil C Tarlatzis, Ioannis Papadimas
Affiliations
Review

Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

Konstantinos A Toulis et al. Eur J Endocrinol. 2010 Apr.

Abstract

Objective: To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF.

Design: Meta-analysis of observational studies.

Patient(s): Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis.

Main outcome measure: Miscarriage risk ratio (RR).

Secondary outcome measures: Clinical pregnancy rate and delivery rate.

Result(s): Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups.

Conclusion: Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.

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