Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Dec 8;106(49):20559-60.
doi: 10.1073/pnas.0911630106. Epub 2009 Dec 1.

Constricting membranes at the nano and micro scale

Olivia L Mooren  1 , Dorothy A Schafer
Affiliations
Comment

Constricting membranes at the nano and micro scale

Olivia L Mooren et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Dynamin GTPase constricts membranes during endocytosis and at epithelial cell apical junctions. Dynamins promote fission of ≈50-nm-diameter membrane tubes to form clathrin-coated vesicles (on right). As described by Chua et al. (1), epithelial cells expressing the mutant dynamin2 protein, dynamin2-K44A (blue cell), become highly constricted, suggesting a new role for dynamin2 in regulating the actomyosin cytoskeleton.
See this image and copyright information in PMC

Comment on

References

    1. Chua J, Rikhy R, Lippincott-Schwartz J. Dynamin2 orchestrates the global actomyosin cytoskeleton for epithelial maintenance and constriction. Proc Natl Acad Sci USA. 2009;106:20770–20775. - PMC - PubMed
    1. Praefcke GJ, McMahon HT. The dynamin superfamily: Universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol. 2004;5:133–147. - PubMed
    1. Stein M, Wandinger-Ness A, Roitbak T. Altered trafficking and epithelial cell polarity in disease. Trends Cell Biol. 2002;12:374–381. - PubMed
    1. Ivanov AI, Nusrat A, Parkos CA. Endocytosis of the apical junctional complex: Mechanisms and possible roles in regulation of epithelial barriers. BioEssays. 2005;27:356–365. - PubMed
    1. Nakayama Y, et al. Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo. Dev Cell. 2009;16:889–900. - PMC - PubMed

Publication types

LinkOut - more resources