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. 2009 Dec;10 Suppl 1(Suppl 1):S5-S15.
doi: 10.1038/gene.2009.85.

Overview of the Rapid Response data

W M Brown  1 , J J Pierce, J E Hilner, L H Perdue, K Lohman, L Lu, P I W de Bakker, K Irenze, L Ziaugra, D B Mirel; Type I Diabetes Genetics Consortium
Affiliations

Overview of the Rapid Response data

W M Brown et al. Genes Immun. 2009 Dec.

Abstract

The Type I Diabetes Genetics Consortium (T1DGC) Rapid Response Workshop was established to evaluate published candidate gene associations in a large collection of affected sib-pair (ASP) families. We report on our quality control (QC) and preliminary family-based association analyses. A random sample of blind duplicates was analyzed for QC. Quality checks, including examination of plate-panel yield, marker yield, Hardy-Weinberg equilibrium, mismatch error rate, Mendelian error rate, and allele distribution across plates, were performed. Genotypes from 2324 families within nine cohorts were obtained from a panel of 21 candidate genes, including 384 single-nucleotide polymorphisms on two genotyping platforms performed at the Broad Institute Center for Genotyping and Analysis (Cambridge, MA, USA). The T1DGC Rapid Response project, following rigorous QC procedures, resulted in a 2297 family, 9688 genotyped individual database on a single-candidate gene panel. The available data include 9005 individuals with genotype data from both platforms and 683 individuals genotyped (276 in Illumina; 407 in Sequenom) on only one platform.

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Conflict of interest statement

Conflict of interest

The authors declare no conflict of interest.

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