Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Apr 20;1(3):211-20.

Integrin signaling aberrations in prostate cancer

Hira Lal Goel  1 , Naved Alam, Isaac N S Johnson, Lucia R Languino
Affiliations

Integrin signaling aberrations in prostate cancer

Hira Lal Goel et al. Am J Transl Res. .

Abstract

Integrins are cell surface receptors for extracellular matrix proteins and play a key role in cell survival, proliferation, migration and gene expression. Integrin signaling has been shown to be deregulated in several types of cancer, including prostate cancer. This review is focused on integrin signaling pathways known to be deregulated in prostate cancer and known to promote prostate cancer progression.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Integrin-dependent signaling pathways. Schematic drawing showing the signal transduction path-ways regulated by integrins that control prostate cancer cell survival, proliferation, adhesion, migration, and cytoskeletal organization. For a detailed description of integrin downstream effectors like Rac, cdc42, Src, Cas, Rho and Crk, or cytoskeletal proteins like AFAP-110, talin and paxillin, readers should refer to previous articles [38, 86].
See this image and copyright information in PMC

References

    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96. - PubMed
    1. Scher HI, Heller G. Clinical states in prostate cancer: toward a dynamic model of disease progression. Urology. 2000;55:323–327. - PubMed
    1. De Marzo AM, Meeker AK, Zha S, Luo J, Na-kayama M, Platz EA, Isaacs WB, Nelson WG. Human prostate cancer precursors and patho-biology. Urology. 2003;62:55–62. - PubMed
    1. Fornaro M, Manes T, Languino LR. Integrins and prostate cancer metastases. Cancer Metastasis Rev. 2001;20:321–331. - PubMed
    1. Demetriou MC, Cress AE. Integrin clipping: a novel adhesion switch? J Cell Biochem. 2004;91:26–35. - PMC - PubMed

LinkOut - more resources