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. 2005 Feb;37(1):24-30.
doi: 10.4143/crt.2005.37.1.24. Epub 2005 Feb 28.

High-dose chemotherapy of cyclophosphamide, thiotepa, and carboplatin (CTCb) followed by autologous stem-cell transplantation for metastatic breast cancer patients: a 6-year follow-up result

Hee-Jung Sohn  1 , Sang-Hee Kim, Gyeong-Won Lee, Shin Kim, Hye Jin Kang, Jin-Hee Ahn, Sung-Bae Kim, Sang-We Kim, Woo Kun Kim, Cheolwon Suh
Affiliations

High-dose chemotherapy of cyclophosphamide, thiotepa, and carboplatin (CTCb) followed by autologous stem-cell transplantation for metastatic breast cancer patients: a 6-year follow-up result

Hee-Jung Sohn et al. Cancer Res Treat. 2005 Feb.

Abstract

Purpose: The benefit of high-dose chemotherapy (HDC) for metastatic breast cancer (MBC) is controversial. We evaluated the efficacy and safety of HDC with cyclophosphamide, thiotepa, and carboplatin (CTCb) followed by autologous stem-cell transplantation (ASCT) for MBC patients.

Materials and methods: From September 1994 to December 1999, 23 MBC patients were enrolled. All the patients received 2 to 10 cycles of induction chemotherapy. Before transplantation, 12 patients were in complete response (CR), nine were in partial response (PR), and two had progressive disease (PD). The HDC regimen consisted of cyclophosphamide 1,500 mg/m(2)/day, thiotepa 125 mg/m(2)/day and carboplatin 200 mg/m(2)/day intravenously for 4 consecutive days.

Results: After ASCT, 13 patients (56%) had a CR, five (22%) had a PR, three (13%) had no change, while two (9%) showed a PD. Seventeen patients relapsed or progressed during the median follow-up of 78 months. The median progression-free survival (PFS) time was 11 months and the median overall survival (OS) time was 23 months. The 5-year PFS and OS rates were 22% and 25%, respectively. On the multivariate analyses, less than 4 involved lymph nodes was predictive of a better PFS and OS.

Conclusion: HDC with CTCb for MBC has acceptable toxicity; however, this treatment does not show a survival benefit.

Keywords: Carboplatin; Cyclophosphamide; High-dose chemotherapy; Metastatic breast neoplasms; Thiotepa.

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Figures

Fig. 1
Fig. 1
(A) Progression-free survival and (B) overall survival (median: 11 and 23 months, respectively).
Fig. 2
Fig. 2
Progression-free survival according to (A) the number of positive nodes (p=0.03) (B) the presence of liver metastases (p=0.028) and (C) the response to induction chemotherapy (p=0.0089).
See this image and copyright information in PMC

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