Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009:2009:624823.
doi: 10.1155/2009/624823. Epub 2009 Feb 26.

Testicular adrenal rest tumours in congenital adrenal hyperplasia

H L Claahsen-van der Grinten  1 , A R M M Hermus, B J Otten
Affiliations

Testicular adrenal rest tumours in congenital adrenal hyperplasia

H L Claahsen-van der Grinten et al. Int J Pediatr Endocrinol. 2009.

Abstract

In adult patients with congenital adrenal hyperplasia (CAH), the presence of testicular adrenal rest tumours (TART) is an important complication leading to gonadal dysfunction and infertility. These tumours can be already found in childhood and puberty. In this paper, we review the embryological, histological, biochemical, and clinical features of TART and discuss treatment options.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Testicular adrenal rest tumour growing into rete testis (RT) (HE, original magnification x 200).
Figure 2
Figure 2
Testicular biopsy of a patient showing seminiferous tubules with hypospermatogenesis and prominent peritubular fibrosis with increased number of peritubular fibroblasts (arrows), as well as tubular hyalinisation (arrow-head; original magnification x 200).
Figure 3
Figure 3
Schematic view of the proposed classification of testicular adrenal rests.
Figure 4
Figure 4
Scrotal ultrasound of a 13-year-old male CAH patient. Transverse image shows a mostly hypoechogenic rounded lesion in the left testis near the rete testis.
Figure 5
Figure 5
T2-weighted MR image of longstanding bilateral testicular adrenal rest tumours in a 33-year-old patient. Note that heterogeneous low-signal-intensity tumours are displacing surrounding high signal normal testicular tissue.
See this image and copyright information in PMC

References

    1. Speiser PW, White PC. Congenital adrenal hyperplasia. The New England Journal of Medicine. 2003;349(8):776–788. - PubMed
    1. Forest MG. Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Human Reproduction Update. 2004;10(6):469–485. - PubMed
    1. Grosse SD, Van Vliet G. How many deaths can be prevented by newborn screening for congenital adrenal hyperplasia? Hormone Research. 2007;67(6):284–291. - PubMed
    1. Wilkins L, Fleishmann W, Howard JE. Macrogenitosomia precox associated with hyperplasia of the androgenic tissue of the adrenal and death from corticoadrenal insufficiency. Endocrinology. 1940;26:385–395.
    1. Shanklin DR, Richardson AP, Jr., Richardson G. Testicular hilar nodules in adrenogenital syndrome. The nature of the nodules. American Journal of Diseases of Children. 1963;106:243–250. - PubMed

LinkOut - more resources