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. 2009 Winter;3(1):33-5.
doi: 10.1097/ICB.0b013e31815e93cf.

Microcystoid maculopathy associated with tamoxifen use diagnosed by high-resolution fourier-domain optical coherence tomography

Susanna S Park  1 , Robert J Zawadzki, Steven N Truong, Stacey S Choi, John S Werner
Affiliations

Microcystoid maculopathy associated with tamoxifen use diagnosed by high-resolution fourier-domain optical coherence tomography

Susanna S Park et al. Retin Cases Brief Rep. 2009 Winter.

Abstract

Purpose: To describe a case of microcystoid maculopathy diagnosed by high-resolution Fourier-domain optical coherence tomography (Fd-OCT) in a patient treated with tamoxifen who had previously unexplained vision loss.

Methods: Report of a case of a 66-year-old woman treated with tamoxifen for 4 years who had progressive unexplained vision loss in the left eye for 2 years.

Results: Visual acuity was 20/25 in the right eye and 20/70 in the left eye. Findings of funduscopy and fluorescein angiography were unremarkable except for minimal pigment alteration in the macula in the left eye. Stratus OCT showed possible microcystoid changes in the fovea in both eyes. Fd-OCT revealed scattered intraretinal microcystoid changes and patches of focal loss of photoreceptors in the macula in both eyes with foveal involvement in the left eye. Full-field electroretinogram was normal. Multifocal electroretinogram showed some decreased response in the peripheral macula and borderline low foveal response in both eyes.

Conclusion: Microcystoid maculopathy associated with tamoxifen use can be diagnosed by Fd-OCT in a normal appearing fundus. It can present as unexplained vision loss.

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Figures

Fig. 1
Fig. 1
Fundus photographs and fluorescein angiograms at presentation. A, Fundus photograph of the right eye is normal. B, Fundus photograph of the left eye shows minimal pigment alteration in the fovea. C, Middle-phase fluorescein angiogram of the right eye is unremarkable. D, Middle-phase fluorescein angiogram of the left eye shows minimal mottled staining in the fovea.
Fig. 2
Fig. 2
Stratus and high-resolution Fourier-domain optical coherence tomography (Fd-OCT) images of both eyes at presentation. Stratus OCT images of the right (A) and left (B) eyes show possible microcystoid changes in the central macula. Fd-OCT images of the right (C) and left (D) eyes show microcystoid changes in the fovea involving the inner nuclear layer (INL) and outer nuclear layer (ONL; arrows). Left eye image also shows focal patches of loss of photoreceptor outer segment layer (OSL) involving the fovea (arrows). NFL, nerve fiber layer.
See this image and copyright information in PMC

References

    1. Kaiser Kupfer MI, Kupfer C, Rodrigues MM. Tamoxifen retinopathy. A clinicopathologic report. Ophthalmology. 1981;88:89–93. - PubMed
    1. Griffiths M. Tamoxifen retinopathy at low dosage. Am J Ophthalmol. 1987;104:185–186. - PubMed
    1. Gualino V, Cohen SY, Delyfer MN, et al. Optical coherence tomography findings in tamoxifen retinopathy. Am J Ophthalmol. 2005;140:757–758. - PubMed
    1. Paunescu LA, Ko TH, Duker JS, et al. Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography. Ophthalmology. 2006;113:48–57. - PMC - PubMed
    1. Alam S, Zawadzki RJ, Choi SC, et al. Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging. Ophthalmology. 2006;113:1425–1431. - PMC - PubMed